An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation. [ GOC:add GOC:dsd PMID:20839338 GO_REF:0000031 PMID:20081059 GOC:rhs GOC:tfm ISBN:0781735149 ]
术语信息
Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.
An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.
术语关系
- B cell, CD19-positive and has plasma membrane part some IgM immunoglobulin complex and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has_not_completed some isotype switching and lacks_plasma_membrane_part some IgD immunoglobulin complex
- B cell, CD19-positive
- has_not_completed some isotype switching
- has part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some IgD immunoglobulin complex
- has part some IgM immunoglobulin complex
- has plasma membrane part some IgM immunoglobulin complex
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- develops from some small pre-B-II cell