A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. [ GOC:amm GO_REF:0000031 http://www.copewithcytokines.de PMCID:PMC2213186 PMCID:PMC548021 PMID:16647566 GOC:dsd GOC:tfm PMID:16551251 ISBN:0721601464 MESH:D055014 http://en.wikipedia.org/wiki/CFU-GM ]
术语信息
Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
colony forming unit granulocyte macrophage
granulocyte/monocyte progenitor
CFU-GM
granulocyte/monocyte precursor
GMP
granulocyte-macrophage progenitor
术语关系
- hematopoietic oligopotent progenitor cell and part of some bone marrow and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2
- bone marrow hematopoietic cell
- hematopoietic oligopotent progenitor cell
- progenitor cell
- myeloid cell
- CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
- lacks_part some erythroid transcription factor
- capable of some granulocyte differentiation
- has part some interleukin-3 receptor class 2 alpha chain
- capable of some macrophage differentiation
- has part some transcription factor PU.1
- has plasma membrane part some interleukin-3 receptor class 2 alpha chain
- has part some CCAAT/enhancer-binding protein alpha
- lacks_part some endothelial transcription factor GATA-2