A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. [ ISBN:0721601464 PMID:20081059 GOC:add ISBN:0781735149 PMID:19447676 PMID:20839338 GO_REF:0000031 GOC:dsd PMID:20951740 http://en.wikipedia.org/wiki/Plasma_cell ]
术语信息
- BTO:0000392
- FMA:70574
Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
术语关系
- antibody secreting cell and has part some cartwheel heterochromatin and has part some Golgi apparatus and has plasma membrane part some syndecan-1 and lacks_plasma_membrane_part some immunoglobulin complex and lacks_plasma_membrane_part some MHC class II protein complex and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- antibody secreting cell
- develops from some plasmablast
- lacks_plasma_membrane_part some immunoglobulin complex
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has part some syndecan-1
- lacks_plasma_membrane_part some MHC class II protein complex
- has part some cartwheel heterochromatin
- has part some Golgi apparatus
- has plasma membrane part some syndecan-1