A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. [ ISBN:0721601464 PMID:12560239 GOC:add PMID:10618520 GOC:dsd GOC:tfm http://www.cap.org PMID:15514007 ]
术语信息-
- FMA:84197
These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin.
术语关系-
- immature neutrophil and has part some acidophilic cytoplasm and has part some reniform nucleus and has part some heterochromatin and has part some azurophil granule and has part some tertiary granule and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some CCAAT/enhancer-binding protein epsilon and has part some neutrophil gelatinase-associated lipocalin and has part some lactotransferrin and has part some myeloperoxidase and has plasma membrane part some integrin alpha-M and has plasma membrane part some alpha-(1,3)-fucosyltransferase 4 and has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III and has plasma membrane part some CD33 molecule and has plasma membrane part some signal transducer CD24 and has plasma membrane part some aminopeptidase N and lacks_plasma_membrane_part some fMet-Leu-Phe receptor
- metamyelocyte
- immature neutrophil
- has part some signal transducer CD24
- has part some transcription factor PU.1
- has plasma membrane part some aminopeptidase N
- has part some CCAAT/enhancer-binding protein alpha
- has part some heterochromatin
- develops from some neutrophilic myelocyte
- has plasma membrane part some CD33 molecule
- lacks_plasma_membrane_part some fMet-Leu-Phe receptor
- has plasma membrane part some alpha-(1,3)-fucosyltransferase 4
- has part some low affinity immunoglobulin gamma Fc region receptor III
- has part some myeloperoxidase
- has part some azurophil granule
- has part some tertiary granule
- has part some neutrophil gelatinase-associated lipocalin
- has part some CD33 molecule
- has part some aminopeptidase N
- has part some reniform nucleus
- has part some CCAAT/enhancer-binding protein epsilon
- has part some lactotransferrin
- has part some alpha-(1,3)-fucosyltransferase 4
- has plasma membrane part some signal transducer CD24
- has part some acidophilic cytoplasm
- has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III