A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative. [ GOC:add GO_REF:0000031 PMID:12457618 PMID:11532393 PMID:15766674 PMID:15032583 GOC:pam ]
术语信息
A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.
术语关系
- lymphoid lineage restricted progenitor cell and has plasma membrane part some CD34 molecule and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some interleukin-2 receptor subunit beta and has plasma membrane part some neprilysin and lacks_plasma_membrane_part some KLRB1-like protein and lacks_plasma_membrane_part some mast/stem cell growth factor receptor
- lymphoid lineage restricted progenitor cell
- has part some interleukin-2 receptor subunit beta
- has part some receptor-type tyrosine-protein phosphatase C isoform CD45RA
- lacks_plasma_membrane_part some KLRB1-like protein
- has plasma membrane part some interleukin-2 receptor subunit beta
- lacks_plasma_membrane_part some mast/stem cell growth factor receptor
- has part some CD34 molecule
- has part some neprilysin
- develops from some common lymphoid progenitor
- has plasma membrane part some CD34 molecule
- has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA
- has plasma membrane part some neprilysin