A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. [ GOC:add PMID:16551251 GOC:dsd ISBN:0781735149 PMID:18432934 PMID:12633665 ]
术语信息
- BTO:0003104
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
pro-B lymphocyte
progenitor B lymphocyte
pro-B-cell
pro-B-lymphocyte
progenitor B cell
progenitor B-lymphocyte
progenitor B-cell
术语关系
- lymphoid lineage restricted progenitor cell and has part some paired box protein PAX-5 and has part some DNA nucleotidylexotransferase and participates in some immunoglobulin V(D)J recombination