negative regulation of canonical Wnt signaling pathway
Go to external page http://purl.obolibrary.org/obo/GO_0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [ GOC:tb GOC:dph ]
术语信息
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of canonical Wnt receptor signaling pathway
negative regulation of Wnt receptor signaling pathway through beta-catenin
negative regulation of canonical Wnt-activated signaling pathway
negative regulation of canonical Wnt receptor signalling pathway
negative regulation of catenin import into nucleus
negative regulation of catenin protein nuclear translocation