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nuclear receptor activity

Go to external page http://purl.obolibrary.org/obo/GO_0004879

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. [ GOC:txnOH-2018 ]

This is just here as a test because I lose it

术语信息

comment

Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.

definition

A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.

has alternative id

GO:0004887

GO:0004886

GO:0038051

GO:0008434

GO:0038050

GO:0003708

GO:0004880

GO:0038052

GO:0004882

GO:0004884

has exact synonym

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding

has narrow synonym

1,25-(OH)2D3 receptor activity

thyroid hormone receptor activity

vitamin D3 receptor activity

glucocorticoid receptor activity

calcitriol receptor activity

ecdysteroid hormone receptor activity

RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding

RXR

RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding

vitamin D receptor activity

retinoid-X receptor activity

retinoic acid receptor activity

nuclear hormone receptor

estrogen nuclear receptor activity

9-cis retinoic acid receptor activity

androgen receptor activity

vitamin A receptor activity

juvenile hormone receptor activity

has obo namespace

molecular_function

has related synonym

ligand-dependent nuclear receptor activity

nuclear receptor activity

ligand-dependent transcription factor activity

id

GO:0004879

term tracker item

https://github.com/geneontology/go-ontology/issues/20253

https://github.com/geneontology/go-ontology/issues/19518