The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.

protein-endoplasmic reticulum insertion

integral ER membrane protein positioning

positioning of protein in ER membrane

protein-ER insertion

integral ER membrane protein localization

protein insertion into endoplasmic reticulum membrane

localization of protein in ER membrane

biological_process

GO:0045048