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transcription coactivator activity

Go to external page http://purl.obolibrary.org/obo/GO_0003713

A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [ PMID:10213677 GOC:txnOH-2018 PMID:16858867 ]

This is just here as a test because I lose it

术语信息

RO 0002161

http://purl.obolibrary.org/obo/NCBITaxon_2

comment

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

creation date

2010-11-24T03:08:19Z

definition

A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

has alternative id

GO:0001105

has exact synonym

transcription co-activator activity

transcription coactivator activity

has obo namespace

molecular_function

has related synonym

RNA polymerase II transcription mediator activity

RNA polymerase II transcription coactivator activity

RNA polymerase II transcription co-activator activity

id

GO:0003713

term tracker item

https://github.com/geneontology/go-ontology/issues/20464

https://github.com/geneontology/go-ontology/issues/20253

https://github.com/geneontology/go-ontology/issues/15998

https://github.com/geneontology/go-ontology/issues/15665