Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [ ISBN:0198547684 GOC:mah ]
术语信息
database
cross reference
- Reactome:R-HSA-5686440 (MUS81:EME1,EME2 cleaves D-loop)
- Reactome:R-HSA-9023941 (MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11)
- Reactome:R-HSA-6782204 (5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER)
- Reactome:R-HSA-5690988 (3'-incision of DNA by ERCC5 (XPG) in GG-NER)
- Reactome:R-HSA-5687464 (MRN and RBBP8 resect DNA DSBs in MMEJ)
- Reactome:R-HSA-5693608 (Initial resection of double-strand break ends)
- Reactome:R-HSA-6782224 (3' incision by ERCC5 (XPG) in TC-NER)
- Reactome:R-HSA-5686657 (ERCC1:XPF cleaves flaps generated by SSA)
- Reactome:R-HSA-5693584 (Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2))
- Reactome:R-HSA-110359 (APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site)
definition
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
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