A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. [ PMID:15771589 GOC:add MESH:A11.329.372.588 PMID:17105582 GOC:tfm GO_REF:0000031 ISBN:0517223651 ]
术语信息
- BTO:0000685
- FMA:14656
Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system.
von Kupffer cell
stellate cell of von Kupffer
littoral cell of hepatic sinusoid
macrophagocytus stellatus
liver macrophage
hepatic macrophage
术语关系
- tissue-resident macrophage and located in some hepatic sinusoid and has plasma membrane part some adhesion G protein-coupled receptor E1 and has plasma membrane part some scavenger receptor cysteine-rich type 1 protein M130 and has plasma membrane part some macrosialin and capable of some erythrocyte clearance and has_low_plasma_membrane_amount some integrin alpha-M
- tissue-resident macrophage
- located in some hepatic sinusoid
- capable of some erythrocyte clearance
- has part some adhesion G protein-coupled receptor E1
- has part some integrin alpha-M
- has part some scavenger receptor cysteine-rich type 1 protein M130
- has_low_plasma_membrane_amount some integrin alpha-M
- has part some macrosialin
- has plasma membrane part some macrosialin
- has plasma membrane part some adhesion G protein-coupled receptor E1
- has plasma membrane part some scavenger receptor cysteine-rich type 1 protein M130