A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [ GOC:cjm GOC:go_curators PMID:21494263 GOC:tb ISBN:0198506732 PMID:18846107 GOC:ecd GOC:mtg_apoptosis GOC:dhl ]
术语信息
- Wikipedia:Apoptosis
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
apoptotic cell death
programmed cell death by apoptosis
apoptotic programmed cell death
apoptosis signaling
apoptosis
type I programmed cell death
apoptotic program
activation of apoptosis
caspase-dependent programmed cell death
commitment to apoptosis
signaling (initiator) caspase activity
induction of apoptosis
induction of apoptosis by p53
apoptosis activator activity
http://purl.obolibrary.org/obo/NCBITaxon_4896
http://purl.obolibrary.org/obo/NCBITaxon_2