A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. [ ISBN:068340007X PMID:9354811 PMCID:PMC1312421 PMID:16455980 PMID:15153310 PMID:19671378 MESH:A11.329.427 GOC:add GOC:dsd PMID:212366338 MESH:D008407 PMCID:PMC2855166 GOC:tfm ]
术语信息
- CALOHA:TS-0603
- FMA:66784
- BTO:0000830
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
术语关系
- myeloid leukocyte and has part some secretory granule and has plasma membrane part some C-C chemokine receptor type 3 and has plasma membrane part some cell surface glycoprotein CD200 receptor 3 and capable of some histamine production involved in inflammatory response and capable of some prostaglandin production involved in inflammatory response and capable of some positive regulation of peripheral tolerance induction and capable of some positive regulation of leukocyte chemotaxis and capable of some positive regulation of type 2 immune response and capable of some heparin biosynthetic process and has_high_plasma_membrane_amount some mast/stem cell growth factor receptor and has_high_plasma_membrane_amount some high affinity immunoglobulin epsilon receptor subunit alpha and lacks_plasma_membrane_part some interleukin-3 receptor class 2 alpha chain
- histamine secreting cell
- myeloid leukocyte
- has part some C-C chemokine receptor type 3
- develops from some mast cell progenitor
- capable of some positive regulation of leukocyte chemotaxis
- has part some mast/stem cell growth factor receptor
- has_high_plasma_membrane_amount some high affinity immunoglobulin epsilon receptor subunit alpha
- capable of some positive regulation of type 2 immune response
- lacks_plasma_membrane_part some interleukin-3 receptor class 2 alpha chain
- has plasma membrane part some cell surface glycoprotein CD200 receptor 3
- capable of some heparin biosynthetic process
- has part some secretory granule
- capable of some positive regulation of peripheral tolerance induction
- capable of some prostaglandin production involved in inflammatory response
- has part some high affinity immunoglobulin epsilon receptor subunit alpha
- capable of some histamine production involved in inflammatory response
- has_high_plasma_membrane_amount some mast/stem cell growth factor receptor
- has part some cell surface glycoprotein CD200 receptor 3
- has plasma membrane part some C-C chemokine receptor type 3