A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. [ GOC:add GO_REF:0000031 PMID:16322748 PMID:20870168 PMID:18303997 PMID:20628149 ]
术语信息
A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.
术语关系
- monocyte and capable of some monocyte chemotaxis and capable of some phagocytosis and capable of some inflammatory response and has_high_plasma_membrane_amount some C-C chemokine receptor type 2 and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- phagocyte
- monocyte
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- capable of some inflammatory response
- has part some C-C chemokine receptor type 2
- lacks_plasma_membrane_part some CD3 epsilon
- lacks_plasma_membrane_part some CD19 molecule
- has_high_plasma_membrane_amount some C-C chemokine receptor type 2
- capable of some monocyte chemotaxis