A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive. [ GOC:add PMID:15514007 PMID:10618520 http://www.cap.org ISBN:0721601464 GOC:tfm PMID:12560239 GOC:dsd ]
术语信息
- FMA:83540
- BTO:0003455
These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive.
术语关系
- immature neutrophil and has part some acidophilic cytoplasm and has part some azurophil granule and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some CCAAT/enhancer-binding protein epsilon and has part some neutrophil gelatinase-associated lipocalin and has part some lactotransferrin and has part some myeloperoxidase and has plasma membrane part some integrin alpha-M and has plasma membrane part some alpha-(1,3)-fucosyltransferase 4 and has plasma membrane part some CD33 molecule and has plasma membrane part some signal transducer CD24 and has plasma membrane part some aminopeptidase N and lacks_part some tertiary granule and lacks_plasma_membrane_part some low affinity immunoglobulin gamma Fc region receptor III
- myelocyte
- immature neutrophil
- nongranular leukocyte
- has part some signal transducer CD24
- lacks_part some tertiary granule
- has part some transcription factor PU.1
- has plasma membrane part some aminopeptidase N
- has part some CCAAT/enhancer-binding protein alpha
- has plasma membrane part some CD33 molecule
- has plasma membrane part some alpha-(1,3)-fucosyltransferase 4
- lacks_plasma_membrane_part some low affinity immunoglobulin gamma Fc region receptor III
- has part some myeloperoxidase
- has part some azurophil granule
- has part some CD33 molecule
- has part some neutrophil gelatinase-associated lipocalin
- has part some aminopeptidase N
- has part some CCAAT/enhancer-binding protein epsilon
- has part some lactotransferrin
- has plasma membrane part some signal transducer CD24
- has part some alpha-(1,3)-fucosyltransferase 4
- has part some acidophilic cytoplasm