This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.

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2011-12-20T02:43:15Z

Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

virus-induced cytoplasmic pattern recognition receptor signaling pathway

cytoplasmic pattern recognition receptor signalling pathway in response to virus

RIG-like helicase signaling pathway

cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway

RIG-I/MDA5 signaling pathway

RIG-like receptor signaling pathway

RIG-I-like receptor (RLR) signaling pathway

RLR signaling pathway

RLH signaling pathway

biological_process

GO:0039528