Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. [ ISBN:0716720094 ]
术语信息
database
cross reference
- Reactome:R-HSA-5693604 (XRCC4:LIG4 ligates DNA DSB ends during NHEJ)
- Reactome:R-HSA-175258 (2-LTR formation due to circularization of viral DNA)
- Reactome:R-HSA-5651789 (LIG1 bound to POLB ligates SSB)
- Reactome:R-HSA-174456 (Joining of adjacent Okazaki fragments of the C-strand)
- Reactome:R-HSA-5690997 (Ligation of newly synthesized repair patch to incised DNA in GG-NER)
- Reactome:R-HSA-69173 (Joining of adjacent Okazaki fragments)
- Reactome:R-HSA-5358592 (DNA ligase I ligates single stranded nick in double stranded DNA)
- Reactome:R-HSA-73931 (LIG3-mediated DNA ligation via the single-nucleotide replacement pathway)
- Reactome:R-HSA-5651805 (LIG1 bound to APEX1 and PCNA ligates SSB)
- Reactome:R-HSA-5649734 (LIG3 ligates NEIL1,NEIL2-generated single strand break)
- Reactome:R-HSA-5687675 (LIG3 ligates remaining SSBs in MMEJ)
- Reactome:R-HSA-6782227 (Ligation of newly synthesized repair patch to incised DNA in TC-NER)
definition
Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.