An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. [ GOC:mah PMID:25192661 PMID:33827924 ]
术语信息
An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
chromatin silencing
transcriptional gene silencing
chromatin-mediated silencing
heterochromatin formation
establishment of heterochromatin architecture
heterochromatin assembly involved in chromatin silencing at pericentric region
establishment of heterochromatin architecture involved in chromatin silencing at pericentric region
heterochromatin formation involved in chromatin silencing at centromere outer repeat region
heterochromatin assembly involved in chromatin silencing at centromere outer repeat region
heterochromatin formation involved in chromatin silencing at pericentric region
establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region
heterochromatic silencing
establishment of chromatin silencing
establishment of heterochromatic silencing
heterochromatin assembly involved in chromatin silencing
heterochromatin formation involved in chromatin silencing
https://github.com/geneontology/go-ontology/issues/19112
https://github.com/geneontology/go-ontology/issues/18954
https://github.com/geneontology/go-ontology/issues/22030