A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [ PMID:10213677 GOC:txnOH-2018 PMID:16858867 ]

This is just here as a test because I lose it

术语信息

comment

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

creation date

2010-11-24T03:14:44Z

definition

A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

has alternative id

GO:0001106

has exact synonym

transcription co-repressor activity

transcription corepressor activity

has obo namespace

molecular_function

has related synonym

RNA polymerase II transcription corepressor activity

RNA polymerase II transcription co-repressor activity

id

GO:0003714

term tracker item

https://github.com/geneontology/go-ontology/issues/20464

https://github.com/geneontology/go-ontology/issues/15998

https://github.com/geneontology/go-ontology/issues/15665