inward rectifier potassium channel activity
Go to external page http://purl.obolibrary.org/obo/GO_0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [ GOC:cb PMID:14977398 GOC:mah ]
术语信息
- Reactome:R-HSA-5678261 (KCNJ11:ABCC9 transports K+ from extracellular region to cytosol)
- Reactome:R-HSA-1369017 (Activation of ATP sensitive Potassium channels in muscle cells)
- Reactome:R-HSA-5678418 (Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol)
- Reactome:R-HSA-1296045 (Activation of Potassium transport channels)
- Reactome:R-HSA-1296046 (KCNJs transport K+ from the extracellular region to cytosol)
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.