nuclear receptor corepressor activity

Go to external page http://purl.obolibrary.org/obo/GO_0140536


A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [ PMID:9238851 PMID:7566126 PMID:7566114 ]

This is just here as a test because I lose it

术语信息

comment

For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.

creation date

2020-11-03T13:02:08Z

definition

A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

has broad synonym

nuclear corepressor activity

has obo namespace

molecular_function

id

GO:0140536

term tracker item

https://github.com/geneontology/go-ontology/issues/20464

https://github.com/geneontology/go-ontology/issues/20262